Halcion is infamous for causing rebound insomnia, but because dentists using this drug off-label are not routinely explaining this special trait associated with Halcion in particular, even used at FDA recommended doses, it’s very likely someone suffering the rebound effects days after the dental appointment will end up, as my daughter did, taking Trazodone, which is often prescribed for insomnia.
As in her case, this is a very very bad idea, and though I knew for years, from observation (because the combination was explosive), that it was a bad idea, I just found this information below that documents it:
“Desyrel [Trazodone]
DRUG INTERACTIONS:
This drug [Trazodone] should not be used with the following medications because very serious interactions may occur: sibutramine, triazolam [Halcion]. [my emphasis]
http://www.rxlist.com/desyrel-drug.htm p10
More about reactions to Trazodone
Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., phenytoin), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone).
TRAZODONE
Trazodone is metabolised by CYP3A4, [SAME AS HALCION] a liver enzyme.[36] Inhibition of this enzyme by various other substances may delay its degradation, leading to high blood levels of trazodone. CYP3A4 may be inhibited by many other medications, herbs, and foods, and as such, trazodone may interact with these substances. One drug-food interaction is grapefruit juice. Drinking grapefruit juice is discouraged in patients taking trazodone. One glass of grapefruit juice occasionally is not likely to have this effect on most people.
[by the way, NO DOC EVER discouraged my daughter from drinking grapefruit juice when they prescribed Trazodone – nor did her dentist mention it in regard to its inhibition of Halcion’s metabolism].
Allergic or toxic
Skin rash, itching, edema, and, rarely, hemolytic anemia, methemoglobinemia, liver enzyme alterations, obstructive jaundice, leukocytoclastic vasculitis, purpuric maculopapular eruptions photosensitivity and fever.
Gastrointestinal
Nausea, vomiting, diarrhea, gastrointestinal discomfort, anorexia, increased appetite.
Cardiovascular
Hypotension, tachycardia, palpitations, shortness of breath, apnea, syncope, arrhythmias, prolonged P-R interval, atrial fibrillation, bradycardia, ventricular ectopic activity (including ventricular tachycardia), myocardial infarction, and cardiac arrest.
http://en.wikipedia.org/wiki/Trazodone
http://www.mentalhealth.com/drug/p30-d03.html
Adverse Effects
The most common adverse reactions encountered are drowsiness, nausea/vomiting, headache and dry mouth. Adverse reactions reported include the following:
Behavioral:
Drowsiness, fatigue, lethargy, retardation, lightheadedness, dizziness, difficulty in concentration, confusion, impaired memory, disorientation, excitement, agitation, anxiety, tension, nervousness, restlessness, insomnia, nightmares, anger, hostility and, rarely, hypomania, visual distortions, hallucinations, delusions and paranoia.
Neurologic:
Tremor, headache, ataxia, akathisia, muscle stiffness, slurred speech, retarded speech, vertigo, tinnitus, tingling of extremities, paresthesia, weakness, grand mal seizures (see Precautions), and, rarely impaired speech, muscle twitching, numbness, dystonia and involuntary movements.
http://www.mentalhealth.com/drug/p30-d03.html
Tell the doctor immediately if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed