[See Chapter 125 (Sept, 2010) for an Index of Subtopics]
Since this blog is about what I call brain robbers -prescription drugs that damage our brains – and since one of the worst of them is Halcion (triazolam), and more important, because of its impact on my daughter’s life and mine, I’m going to start with it.
Though Halcion was banned in the UK, Brazil, and other countries due to some very questionable manufacturer trials, its narrow margin of safety, and many many reports of strange adverse reactions, it remains on the US market.
It’s here not because it’s safe, not because it’s needed, but because the FDA decided to keep it on the market, despite objections from its own scientists, despite more adverse reaction reports on it than on any other drug the FDA regulated at the time.
Now, I know all this sounds like all the rumors every one has heard about the revolving door between the drug industry & the FDA, but in this case, it’s very well documented.
But I don’t want anyone to take my word for it. There happens to be a lot of documentation on the history of this drug, and John Abraham, whose two excellent studies can be found online with a little effort, does the best job of telling it.
“Transnational industrial power, the medical profession and the regulatory state: adverse drug reactions and the crisis over the safety of Halcion in the Netherlands and the UK”
John Abraham
School of Social Sciences, Centre for Research in Health and Medicine (CRHAM), Arts E Building, University of Sussex, Falmer, Brighton BN1 9QN, UK]
And this one explains why the drug stayed on the US market, after the UK banned it.
Abraham J, Sheppard, J 1999 ‘Complacent and conflicting scientific expertise in British and American drug regulation’ Social Studies
of Science 29: 803-44.
Could be, if we could understand the Halcion story, we might be able to understand why a lot of dangerous, but legal drugs are being “pushed” in the US, and we might even be able to answer the question Michael Moore posed in “Bowling for Columbine,” ie.: “Why are there more violent crimes in the US, even though Canada, which has fewer gun-related crimes, has no more restrictions than we do?” — ( I think I got that right-or else Canada’s gun laws are similar to ours, as I understood the movie.) Anyway, no one can argue that we have a lot of gun-related deaths, and we just don’t know how many of those might be committed by people having bad reactions to legal drugs.
If I wondered about this before, I’m sure of it now that I’ve learned so much about Halcion and seen with my own eyes and heart and soul the change it caused in my daughter.
So, Abraham’s work nails it; if you read his studies/investigations, you’ll never wonder if Bill Maher is just shooting off his mouth about the drug industry.
It’s really worse than you think.
But Abraham’s studies are long and academic, so I’ll sum them up here, and you have the links if you want to check me for accuracy, or in case you simply can’t believe that they can get away with what they get away with.
Halcion is approved (and always has been) only for use as a sleeping pill. It is in the benzodiazepine class (benzo-die-AZ-uh-peen) class – same as valium, xanax and others. When Upjohn came up with the formula in the late 60s, it thought it had found a drug superior to valium and other sleeping pills – one that wouldn’t leave you so hung over the next day.
It has a very short half-life, so it works quickly, and gets out of the blood quickly, and so Upjohn thought it was really on to something – something that would make up for disappointing revenues from its other products.
And it did. It first hit the market in Belgium and The Netherlands in 1978 and was a huge financial success for Upjohn.
But a year later, it looked like the party would be over when a doctor, a sleep therapist, named Cees van der Kroef went public with his concerns. Van der Kroef had noticed very strange behavior occurring in his patients after trying Halcion (triazolam -generic name).
The symptoms were so bizarre and so clearly associated
with the drug– and so potentially dangerous–he felt it
necessary to write the country’s minister of health and
“The Lancet ” with his concerns, to which he added a long
list of psychiatric and other observed effects, including
psychosis, depersonalization, severe anorexia, hallucination
and many others. He explained in another instance how
one of his patients, a lawyer who had seen him for insomnia,
developed such a changed personality, she asked him
had he given her LSD.
And, as it turned out, it wasn’t only van der Kroef
reporting strange and serious symptoms; The Dutch
equivalent to our FDA had received numerous complaints of
adverse reactions to the drug, and they took action.
Before banning it altogether, the Dutch asked Upjohn
to simply lower the dose to .25 and include a warning in
the labeling (the drug had been marketed at .5 and 1 mg).
When Upjohn refused, The Netherlands banned it.
Now, by this time the UK was selling the drug as well, but
at the lower doses of .125 and .25 mg, and so when they
heard the news about the Dutch banning Halcion, they
figured it was irrelevant since their dose was lower and
also because they assumed over-reporting of incidents
had occurred after van der Kroef went public, even showing up on a TV program.
They thought all the concern was due to media hype, or at
least that was their excuse, and it’s one being used here
right now, because in the US, the drug is not only
still being used as a sleeping pill (albeit with lower doses
and stronger label warnings), it is being SEXED UP &
RECYCLED as a dental sedative –and being used in
doses higher than 1mg, AND with the blessing, and even encouragement, by a group of dental
“researchers” who routinely downplay it’s past and
even lie about its safety.
I’ll back this up in my next post, just in case you
think “lie” is too strong a word.
From here, go to January 2010, right column (www.brainrobber.com),
and find chapter 3, on page 2 of the January posts — to get the full story about how Upjohn finagled this drug on to the market, despite a premarket history full of fraud, and kept it for sale in the U.S. after others banned it.